There are four types of guidelines that can appear in FotoFusion:

The Safe and Bleed areas are regions used to lay printed material out with precision.
These features are available in the Enhanced, Extreme and Yearbook versions of FotoFusion.
 

Safe & Bleed (Enhanced, Extreme, Yearbook only)
Safe and bleed areas can be added or edited from the Printing Zones area of the Canvas Settings window.
To launch the Canvas Settings window, right-mouse-select outside of your canvas, and choose this option from the drop-down list.
 
You can specify safe and/or bleed zones equal for all four sides of the canvas.
Type this values into the first column, then click on the >> key to transfer these values to the gutter, edge, top and bottom fields.
 
Alternatively, you can set up separate bleed and safe values separately. For instance, you may wish to give a larger safe or a bleed value in the gutter edge, to allow more room for binding.
 

Close up of an autocollage respecting a 1" safe area

Safe zones will create guidelines inside the canvas area, essentially like a margin around the edge of your page.   Some printing companies will suggest using a safe zone to guarantee that any content placed inside the safe area will not be cropped out while being printing. Safe zones can also be use to create a margin around your composition, to give the images more impact. If you perform an AutoCollage on a page with a safe zone, the resulting arrangement of images will be contained within the interior portion of the safe zone. You can manually position images over the safe zone. Images will snap to the guidelines for your convenience, but they can be exceeded

The .25" bleed has inflated this project past the zero line on the ruler. The overall project size is .5 " wider and taller as a result.

Adding a bleed zone will increase the size of your canvas to give your printed documents room to be trimmed. For example, a sheet of business cards or a wedding album page laminated onto a card stock will be produced by physically trimming the edges of the project away, so adding a bleed will pad the canvas size to allow for any cutting imprecision.   It is not recommended to add a bleed unless your professional printing lab has specified it -- you should not add a bleed if you are printing at home or at a consumer-level printing facility. It will inflate your overall canvas size.

Canvas Gridlines
To add a grid to help you position your layout, click on TOOLS on the menu, then Editing, and select GRID SETTINGS.

Snap to Grid: checkmark to turn on a "magnetic" effect when moving or resizing your frames. The white snap lines will gravitate towards the grid's units of measure. The Snap to Grid option is also available in the Tools >> Editing menu.
 
Display Grid Lines: checkmark to make a grid appear on your canvas
 
The RGB values allow you to change the color of the grid lines.
Change the Horizontal and Vertical values (eg. 0.5") to change the spacing of the grid. Hit OK to apply.

To turn off the grid, repeat the steps above and uncheck the SNAP TO GRID or DISPLAY GRID LINES checkbox(es).

You can make any type of grid you would like, such as setting up a page suitable for column or rows, particularly to use with text.
 
If there is a particular grid setup that you will need to use repeatedly, you can make a preset.

Center Guide
Extreme and YearbookFusion users can select "album two page spread" from Page Type section of the Canvas Settings window.
An album two-page spread displays a gutter line will appear in the middle of the page, and can be rendered as "doubles separate" (meaning a separate side will be generated for each side of the page).  Two-page spreads will apply bleed and safe zones to each side of the page, and have separate page numbering for each side of the page.

(Coming soon: center guideline orientation options, to create a layout where the gutter opens from top-to-bottom.)